S. E. Bosinger

Single cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells

The paper uses scRNA-seq to analyze the antiviral response in human dendritic cells infected with ZIKV, identifying a network of host genes and proteins involved in antiviral defense.

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants

This study identifies immune programs linked to COVID-19 severity and mortality through longitudinal multi-omics analysis of 1,152 hospitalized patients.

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

This study shows that modulating type I interferon responses in rhesus macaques reduces SARS-CoV-2 viral load and inflammation, suggesting a potential therapeutic strategy for severe COVID-19.

TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques

This study identifies two macrophage populations driving inflammation in the lower airway during SARS-CoV-2 infection in rhesus macaques and shows baricitinib effectively reduces their influx and cytokine production.

CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection

This study identifies a CCR2-dependent monocyte-derived cell mechanism that restricts SARS-CoV-2 infection and inflammation in the lungs of mice.

From Structure to Sequence: Identification of polyclonal antibody families using cryoEM

This paper uses cryoEM and next-generation sequencing to identify monoclonal antibodies from polyclonal sera and validate their antigen-binding properties.

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

This study shows SARS-CoV-2 infects human airway epithelial cultures, induces pro-inflammatory cytokines, and is inhibited by type I and III IFNs.

Alterations in the human plasma lipidome in response to Tularemia vaccination

This study identifies changes in the plasma lipidome after tularemia vaccination, highlighting key lipid species and their association with inflammation and immune response.

Microbiome Stability with Chronic SIV Infection in AIDS-resistant Sooty Mangabeys

This study compares the gut microbiota stability in SIV-infected sooty mangabeys and rhesus macaques, finding that SMs maintain microbiota stability while RMs show community divergence.

Enhanced Killing of Triple-Negative Breast Cancer Cells by Reassortant Reovirus and Topoisomerase Inhibitors

West Nile virus-inclusive single-cell RNA sequencing reveals heterogeneity in the type I interferon response within single cells

The paper uses WNV-inclusive scRNA-seq to show single-cell heterogeneity in IFN-I response and viral RNA abundance during WNV infection.

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

This study shows that slow delivery immunization in rhesus macaques increases HIV-neutralizing antibody titers and germinal center responses by modulating immunodominance.