M. Bhasin

Single-cell analysis of pediatric acute myeloid leukemia samples uncovers treatment-resistant stem and mast cells

This study uses single-cell RNA sequencing to identify treatment-resistant subtypes and mast cell-like cells in pediatric AML, linking them to poor outcomes.

Single cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells

The paper uses scRNA-seq to analyze the antiviral response in human dendritic cells infected with ZIKV, identifying a network of host genes and proteins involved in antiviral defense.

Targeting TRIP13 in Wilms Tumor with Nuclear Export Inhibitors

This study identifies XPO1 inhibition with selinexor as a potential therapy for favorable histology Wilms tumors, showing synergy with doxorubicin in preclinical models.

Survival Genie, a web platform for survival analysis across pediatric and adult cancers.

Survival Genie enables survival analysis of gene sets, pathways, and single-cell data across cancers to correlate molecular profiles with clinical outcomes.

Prediction of residue-specific contributions to binding and thermal stability using yeast surface display

The paper uses yeast surface display to predict residue-specific contributions to binding and thermal stability, showing high accuracy in identifying buried and active-site residues.

Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment

This paper designs a thermotolerant, immunogenic SARS-CoV-2 RBD protein fragment that is stable at high temperatures and elicits neutralizing antibodies in guinea pigs.

Sustained exposure to trypsin causes cells to transition into a state of reversible stemness that is amenable to transdifferentiation

This paper shows that sustained trypsin exposure induces cells to transition into a reversible stem-like state, enabling transdifferentiation and altering cellular behavior.