A. Mondragon

NRP1-expressing myeloid cells promote arteriogenesis in the ischemic limb

The paper identifies NRP1-expressing myeloid cells as promoters of arteriogenesis in ischemic limbs and suggests their therapeutic potential.

Translational T-box riboswitches bind tRNA by modulating conformational flexibility

This study uses single-molecule FRET to analyze the binding mechanism of the Mycobacterium tuberculosis IleS T-box riboswitch, revealing a two-step model and the role of specific sequences in conformational flexibility and tRNA recognition.

Structures of topoisomerase V in complex with DNA reveal unusual DNA binding mode and novel relaxation mechanism

This study presents structures of topoisomerase V bound to DNA, revealing a novel DNA binding mode and relaxation mechanism distinct from other topoisomerases.

Structural Organization of a Type III-A CRISPR Effector Subcomplex Determined by X-ray Crystallography and Cryo-EM

The paper determines the structural organization of a Type III-A CRISPR effector subcomplex using X-ray crystallography and cryo-EM, revealing details on crRNA binding and complex assembly.

CryoEM structures of open dimers of Gyrase A in complex with DNA illuminate mechanism of strand passage

The paper presents cryoEM structures of open gyrase A dimers with DNA, revealing intermediate states of the catalytic cycle and DNA interactions.

Two-step binding kinetics of tRNAGly by the glyQS T-box riboswitch and its regulation by T-box structural elements

The paper investigates the two-step binding kinetics of tRNAGly by the glyQS T-box riboswitch and identifies structural elements that regulate each step.

Nucleation of multiple buckled structures in intertwined DNA double helices

The paper investigates the statistical-mechanical behavior of intertwined DNA double helices, finding that torsionally stressed braids undergo an abrupt buckling transition with nucleation of end loops and multiple domains.