Author

K. M. Soczek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

J. A. Doudna· 4 shared G. J. Knott· 2 shared A. M. Amen· 1 shared A. M. McKinney· 1 shared A. M. Syed· 1 shared A. Mancini· 1 shared A. Mondragon· 1 shared B. Al-Shayeb· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiochemistry

J. A. Doudna

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Author profile →

5 papers

Recent·Most cited

Genome expansion by a CRISPR trimmer-integrase

J. Y. Wang, O. T. Tuck, P. Skopintsev, K. M. Soczek, G. Li, B. Al-Shayeb, J. Zhou, J. A. Doudna

The paper identifies a CRISPR trimmer-integrase that processes DNA for integration in the absence of Cas4, using cryo-EM structures to show its mechanism.

bioRxiv · Jan 23, 2023Biochemistry

CRISPR-Cas9 bends and twists DNA to read its sequence

J. C. Cofsky, K. M. Soczek, G. J. Knott, E. Nogales, J. A. Doudna

This paper reveals how CRISPR-Cas9 bends and twists DNA to flip nucleotides toward guide RNA for sequence interrogation.

bioRxiv · Sep 6, 2021Biochemistry

Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles

A. M. Syed, T. Y. Taha, M. M. Khalid, T. Tabata, I. P. Chen, B. Sreekumar, P.-Y. Chen, J. M. Hayashi, K. M. Soczek, M. Ott, J. A. Doudna

This study uses SARS-CoV-2 virus-like particles to rapidly assess mutations in viral variants, finding that N protein mutations enhance RNA packaging and viral spread.

bioRxiv · Aug 5, 2021Microbiology

Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage

A. M. Amen, C. Fellmann, K. M. Soczek, S. M. Ren, R. J. Lew, G. J. Knott, J. E. Park, A. M. McKinney, A. Mancini, J. A. Doudna, J. F. Costello

This study shows that reducing GABPB1L in TERT-mutant glioblastomas, combined with chemotherapy, reduces tumor growth by impairing DNA damage response.

Proceedings of the National Academy of Sciences · Mar 23, 2021Peer-reviewedCancer Biology

CryoEM structures of open dimers of Gyrase A in complex with DNA illuminate mechanism of strand passage

K. M. Soczek, T. Grant, P. B. Rosenthal, A. Mondragon

The paper presents cryoEM structures of open gyrase A dimers with DNA, revealing intermediate states of the catalytic cycle and DNA interactions.

bioRxiv · Aug 21, 2018Biophysics