Losartan rewires ovarian cancer tumor-immune microenvironment and suppresses IGF-1 to amplify chemo-immunotherapy sensitivity
Y. Sun, Z. Yin, L. Wu, C. Yue, Y. Zhang, S. Subudhi, P. Lei, A. Muzikansky, L. Zhang, B. R. Rueda, R. K. Jain, L. Xu
This study shows losartan improves chemo-immunotherapy effectiveness in ovarian cancer by altering the tumor microenvironment and reducing IGF-1 signaling in cancer cells.
bioRxiv · Aug 31, 2023 · PreprintCancer Biology