R. K. Jain

Layers in the sand: The genetic imprint of migration, culture, and Indus craft in the Thar desert

This study analyzes genetic diversity in Thar Desert communities, revealing migration, cultural influences, and admixture shaping their genetic landscape.

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

This study profiles metabolites in renal cell carcinoma tissue and fluid to show that nutrient availability is more influenced by tissue-specific factors than tumor-driven changes.

Losartan rewires ovarian cancer tumor-immune microenvironment and suppresses IGF-1 to amplify chemo-immunotherapy sensitivity

This study shows losartan improves chemo-immunotherapy effectiveness in ovarian cancer by altering the tumor microenvironment and reducing IGF-1 signaling in cancer cells.

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma

Losartan prevents ICB-induced cerebral edema and improves survival in glioblastoma mice, with a predictive immune signature identified.

Multi-Species Phenotypic Screening across Disease Models of Mucolipidosis Type IV

The paper screens a compound library across invertebrate and human models of mucolipidosis IV to identify conserved disease modifiers, finding cyclin-dependent kinase inhibition as a potential therapeutic strategy.

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

Shortwave Infrared Fluorescence Imaging with the Clinically Approved Near-Infrared Dye Indocyanine Green

This paper demonstrates that FDA-approved NIR dyes like ICG can be used for SWIR fluorescence imaging in vivo, enabling high-contrast imaging beyond 1500 nm with potential clinical applications.