Molecular basis of proteolytic cleavage regulation by the extracellular matrix receptor dystroglycan
M. J. Anderson, A. N. Hayward, A. T. Smiley, K. Shi, M. R. Pawlak, E. J. Aird, E. Grant, L. Greenberg, H. Aihara, C. Ulens, R. L. Evans, W. R. Gordon
This study identifies a unique mechanism by which dystroglycan is cleaved by MMPs, showing that structural changes disrupt DGC integrity and contribute to disease.
bioRxiv · Apr 4, 2022Biochemistry