Author

E. J. Aird

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

W. R. Gordon· 3 shared H. Aihara· 2 shared K. J. Tompkins· 2 shared K. Shi· 2 shared R. L. Evans· 2 shared A. N. Hayward· 1 shared A. T. Nelson· 1 shared A. T. Smiley· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiochemistry

W. R. Gordon

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Author profile →

4 papers

Recent·Most cited

SP110 sequestration of SP100 protects against toxic filaments during innate immune signaling

E. J. Aird, J. Rabl, T. Knuesel, L. Scherpe, D. Boehringer, J. E. Corn

The paper identifies SP110 as a negative regulator of type 1 interferon-driven cell death by counteracting SP100's toxic filament formation through CARD domain interactions.

bioRxiv · Apr 3, 2024Immunology

Molecular basis of proteolytic cleavage regulation by the extracellular matrix receptor dystroglycan

M. J. Anderson, A. N. Hayward, A. T. Smiley, K. Shi, M. R. Pawlak, E. J. Aird, E. Grant, L. Greenberg, H. Aihara, C. Ulens, R. L. Evans, W. R. Gordon

This study identifies a unique mechanism by which dystroglycan is cleaved by MMPs, showing that structural changes disrupt DGC integrity and contribute to disease.

bioRxiv · Apr 4, 2022Biochemistry

Molecular underpinnings of ssDNA specificity by Rep HUH endonucleases and implications for HUH-tag multiplexing and engineering

K. J. Tompkins, M. Houtti, L. A. Litzau, E. J. Aird, B. A. Everett, A. T. Nelson, L. Pornschloegl, L. K. Limon-Swanson, R. L. Evans, K. Evans, K. Shi, H. Aihara, W. R. Gordon

The paper investigates the molecular mechanism of ssDNA specificity by HUH-endonucleases and demonstrates how this can be engineered for multiplexed HUH-tagging and bioconjugation.

bioRxiv · Sep 1, 2020Biophysics

An enhanced molecular tension sensor based on bioluminescence resonance energy transfer (BRET)

W. R. Gordon, E. J. Aird, K. J. Tompkins

This paper develops a BRET-based molecular tension sensor with improved spectral properties and dynamic range compared to FRET-based sensors, demonstrating its application in studying tension gradients in focal adhesions.

bioRxiv · Apr 24, 2019Cell Biology