Author

W. R. Gordon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2 Cell Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Assay:DNA methylation· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

R. L. Evans· 4 shared E. J. Aird· 3 shared H. Aihara· 3 shared K. J. Tompkins· 3 shared K. Shi· 3 shared A. T. Nelson· 2 shared A. T. Smiley· 2 shared B. A. Everett· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersBiophysics

R. L. Evans

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Designing Efficient Enzymes: Eight Predicted Mutations Convert a Hydroxynitrile Lyase into an Efficient Esterase

G. Casadevall, C. T. Pierce, B. Guan, J. Iglesias-Fernandez, H.-Y. Lim, L. R. Greenberg, M. E. Walsh, K. Shi, W. R. Gordon, H. Aihara, R. L. Evans, R. J. Kazlauskas, S. Osuna

The paper identifies eight mutations that convert a hydroxynitrile lyase into an efficient esterase by correcting structural differences using shortest path maps.

bioRxiv · Aug 23, 2023 · PreprintBioengineering

RAD-TGTs: Measurement of cellular tensions via flow cytometry and DNA sequencing enabled by force-dependent rupture and delivery of DNA tension probes

M. R. Pawlak, A. T. Smiley, M. D. Kelly, G. A. Shamsan, S. M. Anderson, B. A. Smeester, D. A. Largaespada, D. J. Odde, W. R. Gordon

The paper introduces RAD-TGTs, a method to measure cellular tensions using DNA duplexes that rupture under force, with readout via flow cytometry and DNA sequencing.

bioRxiv · Nov 8, 2022 · PreprintBiophysics

Molecular basis of proteolytic cleavage regulation by the extracellular matrix receptor dystroglycan

M. J. Anderson, A. N. Hayward, A. T. Smiley, K. Shi, M. R. Pawlak, E. J. Aird, E. Grant, L. Greenberg, H. Aihara, C. Ulens, R. L. Evans, W. R. Gordon

This study identifies a unique mechanism by which dystroglycan is cleaved by MMPs, showing that structural changes disrupt DGC integrity and contribute to disease.

bioRxiv · Apr 4, 2022Biochemistry

Dystrophin modulates focal adhesion tension and YAP-mediated mechanotransduction

M. P. Ramirez, M. J. Anderson, L. J. Sundby, A. R. Hagerty, S. J. Wenthe, J. M. Ervasti, W. R. Gordon

This study investigates how dystrophin mutations affect focal adhesion tension and YAP-mediated mechanotransduction in myoblasts.

bioRxiv · Aug 5, 2021 · PreprintCell Biology

Molecular underpinnings of ssDNA specificity by Rep HUH endonucleases and implications for HUH-tag multiplexing and engineering

K. J. Tompkins, M. Houtti, L. A. Litzau, E. J. Aird, B. A. Everett, A. T. Nelson, L. Pornschloegl, L. K. Limon-Swanson, R. L. Evans, K. Evans, K. Shi, H. Aihara, W. R. Gordon

The paper investigates the molecular mechanism of ssDNA specificity by HUH-endonucleases and demonstrates how this can be engineered for multiplexed HUH-tagging and bioconjugation.

bioRxiv · Sep 1, 2020Biophysics

Student-focused development of a next-generation centrifuge force microscope

K. J. Tompkins, E. T. Berscheid, N. Venkatesh, A. J. Andrew, A. P. Beckman, M. A. Esler, A. C. Evans, B. A. Everett, M. Houtti, H. Koo, L. A. Litzau, A. T. Nelson, T. M. Peterson, T. A. Reid, R. L. Evans, W. R. Gordon

This paper describes the development of an affordable centrifuge force microscope (CFM) by students, emphasizing educational value and hands-on research experience.

bioRxiv · Aug 30, 2020 · PreprintBiophysics

Interrogating mechanisms of ssDNA binding to a viral HUH-endonuclease by alanine scanning of an electrostatic patch

A. Nelson, K. Tompkins, M. P. Ramirez, W. R. Gordon

This study investigates the mechanism of ssDNA binding by a viral HUH-endonuclease through alanine scanning of an electrostatic patch, revealing key residues critical for binding specificity and activity.

bioRxiv · Dec 4, 2019 · PreprintBiochemistry

An enhanced molecular tension sensor based on bioluminescence resonance energy transfer (BRET)

W. R. Gordon, E. J. Aird, K. J. Tompkins

This paper develops a BRET-based molecular tension sensor with improved spectral properties and dynamic range compared to FRET-based sensors, demonstrating its application in studying tension gradients in focal adhesions.

bioRxiv · Apr 24, 2019Cell Biology