Author

R. L. Evans

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:plant (other)· 1 Research Focus:protein design· 1

Frequent Co-Authors

W. R. Gordon· 4 shared H. Aihara· 3 shared K. Shi· 3 shared A. T. Nelson· 2 shared B. A. Everett· 2 shared B. Guan· 2 shared E. J. Aird· 2 shared K. J. Tompkins· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersBiophysics

W. R. Gordon

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Designing Efficient Enzymes: Eight Predicted Mutations Convert a Hydroxynitrile Lyase into an Efficient Esterase

G. Casadevall, C. T. Pierce, B. Guan, J. Iglesias-Fernandez, H.-Y. Lim, L. R. Greenberg, M. E. Walsh, K. Shi, W. R. Gordon, H. Aihara, R. L. Evans, R. J. Kazlauskas, S. Osuna

The paper identifies eight mutations that convert a hydroxynitrile lyase into an efficient esterase by correcting structural differences using shortest path maps.

bioRxiv · Aug 23, 2023 · PreprintBioengineering

Molecular basis of proteolytic cleavage regulation by the extracellular matrix receptor dystroglycan

M. J. Anderson, A. N. Hayward, A. T. Smiley, K. Shi, M. R. Pawlak, E. J. Aird, E. Grant, L. Greenberg, H. Aihara, C. Ulens, R. L. Evans, W. R. Gordon

This study identifies a unique mechanism by which dystroglycan is cleaved by MMPs, showing that structural changes disrupt DGC integrity and contribute to disease.

bioRxiv · Apr 4, 2022Biochemistry

Molecular underpinnings of ssDNA specificity by Rep HUH endonucleases and implications for HUH-tag multiplexing and engineering

K. J. Tompkins, M. Houtti, L. A. Litzau, E. J. Aird, B. A. Everett, A. T. Nelson, L. Pornschloegl, L. K. Limon-Swanson, R. L. Evans, K. Evans, K. Shi, H. Aihara, W. R. Gordon

The paper investigates the molecular mechanism of ssDNA specificity by HUH-endonucleases and demonstrates how this can be engineered for multiplexed HUH-tagging and bioconjugation.

bioRxiv · Sep 1, 2020Biophysics

Student-focused development of a next-generation centrifuge force microscope

K. J. Tompkins, E. T. Berscheid, N. Venkatesh, A. J. Andrew, A. P. Beckman, M. A. Esler, A. C. Evans, B. A. Everett, M. Houtti, H. Koo, L. A. Litzau, A. T. Nelson, T. M. Peterson, T. A. Reid, R. L. Evans, W. R. Gordon

This paper describes the development of an affordable centrifuge force microscope (CFM) by students, emphasizing educational value and hands-on research experience.

bioRxiv · Aug 30, 2020 · PreprintBiophysics

Larger active site in an ancestral hydroxynitrile lyase increases catalytically promiscuous esterase activity

B. Jones, R. L. Evans, N. Mylrea, D. Chaudhury, C. Luo, C. Pierce, B. Guan, W. Gordon, C. Wilmot, R. Kazlauskas

This paper reconstructs an ancestral hydroxynitrile lyase, HNL1, which has a larger active site and increased catalytic promiscuity compared to modern HbHNL.

bioRxiv · Apr 6, 2020Biochemistry