Author

A. N. Koppes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

R. A. Koppes· 4 shared D. T. Breault· 2 shared J. R. Soucy· 2 shared A. Ghio· 1 shared A. S. Sharma· 1 shared A. W. Lunger· 1 shared B. M. Woolston· 1 shared C. Ghio· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBioengineering

R. A. Koppes

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5 papers

Recent·Most cited

Engineered bacteria titrate hydrogen sulfide and induce concentration-dependent effects on host in a gut microphysiological system

J. A. Hayes, A. W. Lunger, A. S. Sharma, M. T. Fernez, R. A. Koppes, A. N. Koppes, B. M. Woolston

This study engineers E. coli to control H2S levels in a gut chip system, showing concentration-dependent effects on host gene expression and metabolism.

bioRxiv · May 16, 2023Bioengineering

Lactate production can function to increase human epithelial cell iron concentration

C. Ghio, J. M. Soukup, L. A. Dailey, A. Ghio, D. M. Schreinemachers, R. A. Koppes, A. N. Koppes

This study shows lactate can enhance iron import in human epithelial cells, LDH activity reflects iron availability, and blood LDH correlates with iron homeostasis indices.

bioRxiv · Nov 11, 2021Bioengineering

Innervated adrenomedullary microphysiological system to model prenatal nicotine and opioid exposure

J. R. Soucy, G. Burchett, R. Brady, D. T. Breault, A. N. Koppes, R. A. Koppes

The paper develops an innervated 3D microphysiological system to study how prenatal nicotine and opioid exposure affect adrenomedullary catecholamine release under hypoxia.

bioRxiv · Sep 22, 2020 · PreprintBioengineering

Rapid prototyping of a multilayer microphysiological system for primary human intestinal epithelial culture

S. Hosic, M. L. Puzan, W. Lake, F. Zhou, R. A. Koppes, D. T. Breault, S. K. Murthy, A. N. Koppes

This paper describes a rapid, economical method for fabricating multilayer organs-on-chips using laser cutting and assembly, demonstrating its effectiveness for culturing primary human intestinal epithelial cells and organoids.

bioRxiv · Aug 27, 2018Bioengineering

Glial cells in the heart? Replicating the diversity of the myocardium with low-cost 3D models

J. R. Soucy, J. Askaryan, D. Diaz, A. N. Koppes, N. Annabi, R. Koppes

The paper develops 3D cardiac tissue models to study the role of non-muscle cells in heart function, showing that Schwann cells affect cardiomyocyte electrical coupling.

bioRxiv · Apr 23, 2018Bioengineering