D. T. Breault

β-catenin programs a tissue-specific epigenetic vulnerability in aggressive adrenocortical carcinoma

This study shows that β-catenin maintains adrenocortical carcinoma differentiation through chromatin and histone interactions, and that targeting EZH2 can disrupt this process and inhibit tumor growth.

Establishment of physiologically relevant oxygen gradients in microfluidic organ chips

This paper establishes a method to create physiologically relevant oxygen gradients in a microfluidic intestine-on-a-chip model, supporting stable oxygen levels and intestinal barrier integrity.

Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers.

This study uses human ileal enteroid-derived monolayers to show that Yersinia pseudotuberculosis YopE prevents uptake by M cells and causes their extrusion, facilitating bacterial transcytosis.

Innervated adrenomedullary microphysiological system to model prenatal nicotine and opioid exposure

The paper develops an innervated 3D microphysiological system to study how prenatal nicotine and opioid exposure affect adrenomedullary catecholamine release under hypoxia.

Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture

This study develops a co-culture platform to study interactions between human colonic mucosal barriers and Faecalibacterium prausnitzii, showing anti-inflammatory effects and butyrate's role in modulating TLR3/4.

Human colon-on-a-chip enables continuous in vitro analysis of colon mucus layer accumulation and physiology

This study develops a human colon-on-a-chip model that replicates the mucus bilayer structure and function, enabling real-time non-invasive analysis of mucus layer dynamics.

Species-specific enhancement of enterohemorrhagic E. Coli pathogenesis mediated by microbiome metabolites

The paper identifies human gut microbiome metabolites that enhance EHEC pathogenesis in a human colonic organ chip model, contributing to species-specific susceptibility.

Rapid prototyping of a multilayer microphysiological system for primary human intestinal epithelial culture

This paper describes a rapid, economical method for fabricating multilayer organs-on-chips using laser cutting and assembly, demonstrating its effectiveness for culturing primary human intestinal epithelial cells and organoids.