Author

J. A. Hayes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Assay:cryo-EM· 1 Organism:E. coli· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. A. Kelch· 3 shared N. P. Stone· 3 shared B. J. Hilbert· 2 shared C. Gaubitz· 2 shared A. N. Koppes· 1 shared A. S. Sharma· 1 shared A. W. Lunger· 1 shared B. M. Woolston· 1 shared

Activity by Year

2016-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

B. A. Kelch

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Evidence for peripheral and central actions of codeine to dysregulate deglutition in the anesthetized cat

D. C. Bolser, T. Shen, M. N. Musselwhite, M. J. Rose, J. A. Hayes, T. Pitts

This study investigates codeine's effects on swallowing in anesthetized cats, finding both central and peripheral mechanisms contributing to dysregulated swallowing.

bioRxiv · Nov 7, 2023 · PreprintPhysiology

Engineered bacteria titrate hydrogen sulfide and induce concentration-dependent effects on host in a gut microphysiological system

J. A. Hayes, A. W. Lunger, A. S. Sharma, M. T. Fernez, R. A. Koppes, A. N. Koppes, B. M. Woolston

This study engineers E. coli to control H2S levels in a gut chip system, showing concentration-dependent effects on host gene expression and metabolism.

bioRxiv · May 16, 2023Bioengineering

Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

C. Gaubitz, X. Liu, J. Pajak, N. P. Stone, J. A. Hayes, G. Demo, B. A. Kelch

The paper presents cryo-EM structures of the yeast clamp loader RFC bound to PCNA, revealing the mechanism of clamp opening and DNA binding without ATP hydrolysis.

bioRxiv · Sep 23, 2021Biochemistry

A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry

J. A. Hayes, B. J. Hilbert, C. Gaubitz, N. P. Stone, B. A. Kelch

This paper identifies and characterizes the TerS protein of bacteriophage P74-26, revealing its unique structural features and functional roles in DNA binding and TerL interaction.

bioRxiv · Nov 21, 2019Biochemistry

The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain

B. J. Hilbert, J. A. Hayes, N. P. Stone, R.-G. Xu, B. A. Kelch

This study investigates how the large terminase protein binds and cleaves DNA during viral genome packaging, revealing the ATPase domain's role in DNA binding and the nuclease domain's role in cleavage.

bioRxiv · Oct 19, 2016Biochemistry