Author

T. C. Larman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Zhu· 2 shared M. Zeineldin· 2 shared R. Li· 2 shared Y. Dong· 2 shared A. Gupta· 1 shared A. Liu· 1 shared A. M. De Marzo· 1 shared A. Narkar· 1 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

J. Zhu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

Y. Dong, B. A. Johns, L. Ruan, M. Zeineldin, A. Liu, S. Raychaudhuri, I. Chiu, J. Zhu, B. Smith, N. Zhao, P. Searson, S. Watanabe, M. Donowitz, T. C. Larman, R. Li

This study shows inflammation-associated fibroblasts disrupt colon epithelial barrier integrity and genome stability via PGE2-EP4 signaling, and EP4 inhibitors can reverse these effects.

Science Advances · Apr 5, 2024Peer-reviewedCell Biology

Differential effects of aneuploidy on growth and differentiation in human intestinal stem cells

B. A. Johnson, A. Z. Liu, T. Bi, Y. Dong, T. Li, D. Zhou, A. Narkar, Y. Wu, S. Sun, T. C. Larman, J. Zhu, R. Li

This study investigates how different types of aneuploidy affect growth and differentiation in human intestinal stem cells, finding that complex aneuploidy triggers p53 activation and cell-cycle arrest, while simple aneuploidy allows continued proliferation and impaired differentiation.

bioRxiv · Sep 23, 2023 · PreprintCell Biology

MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression

J. Chen, Q. Zheng, J. L. Hicks, L. Trabzonlu, B. Ozbek, T. Jones, A. Vaghasia, T. C. Larman, R. Wang, M. C. Markowski, S. R. Denmeade, K. J. Pienta, R. H. Hruban, E. S. Antonarakis, A. Gupta, , A. M. De Marzo

The paper develops a method to spatially quantify mitochondrial DNA copy number in cancer tissues and finds increased mtDNAcn in prostate cancer progression, linked to MYC activity.

bioRxiv · Feb 20, 2023Cancer Biology

SATB2 loss in inflammatory bowel disease-associated small intestinal metaplasia of the distal colon

M. Zeineldin, T. C. Larman

The paper shows SATB2 loss is associated with preneoplastic metaplasia in IBD-related chronic colitis, linking it to small intestinal metaplasia and increased cancer risk.

bioRxiv · Feb 1, 2023 · PreprintPathology