Author

A. G. Fletcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Assay:imaging· 2 Approach:mechanistic / dynamical model· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. M. Cammarota· 2 shared D. T. Bergstralh· 2 shared J. G. Scott· 2 shared N. S. Dawney· 2 shared P. K. Maini· 2 shared P. M. Bellomio· 2 shared A. Chumakova· 1 shared A. Dhawan· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

C. M. Cammarota

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The Mechanical Influence of Densification on Initial Epithelial Architecture

C. M. Cammarota, N. S. Dawney, P. M. Bellomio, M. Jung, A. G. Fletcher, T. M. Finegan, D. T. Bergstralh

The paper investigates how cell density and mechanical constraints influence epithelial architecture transitions, showing that crowding drives the first transition and adhesion drives the second.

bioRxiv · May 7, 2023 · PreprintCell Biology

Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins

A. Schmidt, T. Finegan, M. Haring, D. Kong, A. G. Fletcher, Z. Alam, J. Grosshans, F. Wolf, M. Peifer

The paper investigates the role of Drosophila Polychaetoid/ZO-1 in strengthening cell junctions under tension and its distinct localization compared to core adherens junction proteins.

bioRxiv · Mar 1, 2023Cell Biology

Competition Between Cell-Cell and Cell-Substrate Adhesion Determines Epithelial Monolayer Architecture in Culture

C. M. Cammarota, N. S. Dawney, Q. Jia, M. M. Jung, J. A. Glichowski, P. M. Bellomio, A. G. Fletcher, D. T. Bergstralh

The paper investigates how cell-cell and cell-substrate adhesion balance determines epithelial monolayer architecture in cultured MDCK cells.

bioRxiv · Sep 13, 2021 · PreprintCell Biology

Adhesion dynamics regulate cell intercalation behaviour in an active tissue

A. Nestor-Bergmann, G. Blanchard, N. Hervieux, A. G. Fletcher, J. Etienne, B. Sanson

This paper develops a mechanical model to study cell intercalation in epithelial tissues, showing that junctional dynamics and adhesion friction regulate neighbour exchanges and tissue deformation.

bioRxiv · Apr 11, 2021 · PreprintBiophysics

Recasting the cancer stem cell hypothesis: unification using a continuum model of microenvironmental forces

J. G. Scott, A. Dhawan, A. Hjelmeland, J. Lathia, A. Chumakova, M. Hitomi, A. G. Fletcher, P. K. Maini, A. R. A. Anderson

The paper unifies the cancer stem cell and stochastic models using a continuum model of microenvironmental forces, supported by clonogenic assay results.

Current Stem Cell Reports · Feb 15, 2019Peer-reviewedCancer Biology

Inferring Tumour Proliferative Organisation from Phylogenetic Tree Measures in a Computational Model

J. G. Scott, A. R. Anderson, P. K. Maini, A. G. Fletcher

This study uses computational modeling to infer tumour proliferative hierarchy by analyzing phylogenetic tree measures under cancer stem cell and neutral evolution assumptions.

bioRxiv · Nov 23, 2018Cancer Biology