A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis
E. Schiebel, W. Zhang, A. Khan, J. Vitale, A. Neuner, K. Rink, C. Luechtenborg, B. Bruegger, T. Soellner
The paper identifies an amphipathic α-helix in Apq12 that regulates NPC biogenesis by modulating Brl1 and Brr6 interactions and phosphatidic acid accumulation at the nuclear envelope.
bioRxiv · Aug 13, 2021Cell Biology