Regulation of lipid accumulation-induced ROS in myeloid-derived suppressor cells via targeting fatty-acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy
A. O. Adeshakin, W. Liu, F. O. Adeshakin, L. O. Afolabi, M. Zhang, G. Zhang, L. Wang, Z. Li, L. Lin, D. Yan, X. Wan
This study shows that inhibiting FATP2 in MDSCs reduces ROS and enhances anti-PD-L1 immunotherapy by improving T-cell function and reducing PD-L1 expression.
bioRxiv · Sep 28, 2020Immunology