G. R. Smith

Comparative single cell analysis reveals complex patterns of cell type and cell signaling innovations at the fetal-maternal interface

This paper compares single-cell data across six mammalian species to uncover evolutionary patterns in cell types and signaling at the fetal-maternal interface, finding conserved gene signatures and stepwise evolution of decidual cells.

Enhanced local cooling effects of forests across the globe

The paper quantifies how forest cooling effects on land surface temperatures have increased with climate change, emphasizing the need to protect forests as temperatures rise.

Genetic drift and genome reduction in the plant pathogen Candidatus Liberibacter solanacearum shapes a new enzyme in lysine biosynthesis.

This study examines how genome reduction and genetic drift in Candidatus Liberibacter solanacearum affect the function of its dihydrodipicolinate synthase, revealing structural and kinetic changes in the enzyme.

Global trade-offs in tree functional traits

The paper quantifies global trait variation in trees, identifying two independent processes and seven key traits that capture most variation in tree form and function.

Single nucleus pituitary transcriptomic and epigenetic landscape reveals human stem cell heterogeneity with diverse regulatory mechanisms

The paper characterizes human pituitary stem cells using single nucleus RNA-seq and ATAC-seq, revealing distinct cell types, regulatory mechanisms, and age-related differences.

mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge

This study evaluates mRNA-1273 vaccine efficacy in hamsters, showing reduced pulmonary immune activation and improved disease outcomes after prime-boost vaccination.

Single nucleus multi-omics regulatory atlas of the murine pituitary

The paper creates a single nucleus multi-omics atlas of the murine pituitary, revealing cell type-specific regulatory mechanisms and identifying a cis-regulatory region linked to fertility.