Author

M. L. Lynch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:machine learning (classical)· 2 Assay:protein structure· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. A. Babbitt· 3 shared A. O. Hudson· 2 shared E. P. Fokoue· 2 shared P. Rynkiewicz· 2 shared A. Gupta· 1 shared A. Woloszynska· 1 shared C. J. Ryan· 1 shared F. Cui· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiophysics

G. A. Babbitt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ATOMDANCE: kernel-based denoising and allosteric resonance analysis for functional and evolutionary comparisons of protein dynamics

G. A. Babbitt, M. Rajendran, M. L. Lynch, R. Asare-Bediako, L. T. Mouli, C. J. Ryan, H. Srivastava, P. Rynkiewicz, K. Phadke, M. L. Reed, N. Moore, M. C. Ferran, E. P. Fokoue

ATOMDANCE compares and denoises protein motion dynamics between functional or evolutionary states using kernel-based methods to identify key sites and functional shifts.

bioRxiv · Apr 20, 2023Biophysics

DDK inhibition disrupts replication leading to mitotic catastrophe in Ewing sarcoma

J. C. Martin, A. Gupta, T. J. Hagoel, L. Gao, M. L. Lynch, A. Woloszynska, T. Melendy, J. Kane, J. Kuechle, J. Ohm

This study shows that DDK inhibition causes replication stress and mitotic catastrophe in Ewing sarcoma cells, reducing viability and suggesting DDK as a therapeutic target.

bioRxiv · Nov 2, 2021 · PreprintCancer Biology

Functional binding dynamics relevant to the evolution of zoonotic spillovers in endemic and emergent Betacoronavirus strains

P. Rynkiewicz, G. A. Babbitt, F. Cui, A. O. Hudson, M. L. Lynch

The paper uses machine learning on molecular dynamics simulations to analyze conserved functional binding dynamics between Betacoronavirus strains and ACE2/CD26, identifying pre-adapted regions linked to zoonotic spillovers.

bioRxiv · Sep 11, 2020 · PreprintBiophysics

Function and evolution of B-Raf loop dynamics relevant to cancer recurrence under drug inhibition

G. A. Babbitt, M. L. Lynch, M. McCoy, E. P. Fokoue, A. O. Hudson

This study uses molecular dynamics simulations and machine learning to analyze how B-Raf loop dynamics change under drug inhibition and genetic mutations, showing that ATP competitive inhibitors reduce hyperactivation risks.

bioRxiv · Jan 13, 2020Biophysics