THE RIBOREGULATION MECHANISM OF HUMAN SERINE HYDROXYMETHYLTRANSFERASE IS ROOTED IN AN ALLOSTERIC SWITCH
S. Spizzichino, F. Di Fonzo, C. Marabelli, A. Tramonti, A. Chaves-Sanjuan, A. Parroni, G. Boumis, F. R. Liberati, A. Paone, L. C. Montemiglio, M. Ardini, A. J. Jakobi, A. Bharadwaj, P. Swuec, G. G. Tartaglia, , F. Cutruzzola
This study identifies an allosteric RNA switch mechanism regulating SHMT1 activity, revealing structural elements critical for RNA binding and implications for RNA-based therapies.
bioRxiv · Mar 17, 2023Biochemistry