G. G. Tartaglia

This paper introduces a fluorescence lifetime fluctuation spectroscopy framework to study bio-molecular condensate formation in live cells under oxidative stress.

This study identifies an allosteric RNA switch mechanism regulating SHMT1 activity, revealing structural elements critical for RNA binding and implications for RNA-based therapies.

PENGUIN reconstructs protein interactions at enhancer-promoter regions and identifies cancer-associated SNPs in prostate cancer cell lines.

This study shows that RNA sequestration occurs during protein aggregation, with a mutant alpha synuclein variant showing stronger RNA binding than the wild-type.

The paper predicts A-to-I RNA modifications' effects on RNA structure and finds increased double-stranded content in non-coding RNAs.

The paper uses rec-Y2H screening to identify direct protein-protein interactions among RNA-binding proteins, revealing new interactions and their implications for RNA processing and cancer.

The paper shows that N1-methyladenine (m1A) protects mRNAs from aberrant RNA-protein interactions during proteostasis stress, such as heat shock and amyloidogenesis.

The paper identifies RNA-associated proteins in heat-shocked mammalian cells and shows their role in RNA granule formation during proteostasis stress.