Author

A. Chaves-Sanjuan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

M. Bolognesi· 4 shared S. Ricagno· 2 shared A. Bartolome-Nafria· 1 shared A. Bharadwaj· 1 shared A. J. Jakobi· 1 shared A. M. Anastasi· 1 shared A. Paiardini· 1 shared A. Paone· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersBiochemistry

M. Bolognesi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

THE RIBOREGULATION MECHANISM OF HUMAN SERINE HYDROXYMETHYLTRANSFERASE IS ROOTED IN AN ALLOSTERIC SWITCH

S. Spizzichino, F. Di Fonzo, C. Marabelli, A. Tramonti, A. Chaves-Sanjuan, A. Parroni, G. Boumis, F. R. Liberati, A. Paone, L. C. Montemiglio, M. Ardini, A. J. Jakobi, A. Bharadwaj, P. Swuec, G. G. Tartaglia, , F. Cutruzzola

This study identifies an allosteric RNA switch mechanism regulating SHMT1 activity, revealing structural elements critical for RNA binding and implications for RNA-based therapies.

bioRxiv · Mar 17, 2023Biochemistry

Cryo-EM Structure of a Mammalian-specific Alternative Amyloid Exon

J. Garcia-Pardo, A. Bartolome-Nafria, A. Chaves-Sanjuan, M. Gil-Garcia, C. Visentin, M. Bolognesi, S. Ricagno, S. Ventura

The paper presents the cryo-EM structure of hnRNPDL-2 amyloid fibrils, showing how alternative splicing controls RNP assembly through an amyloid exon.

bioRxiv · Aug 24, 2022 · PreprintBiochemistry

Spike mutation resilient scFv76 antibody counteracts SARS-CoV-2 lung damage upon aerosol delivery

F. M. Milazzo, A. Chaves-Sanjuan, O. Minenkova, D. Santapaola, A. M. Anastasi, G. Battistuzzi, C. Chiapparino, A. Rosi, E. Merlo Pich, C. Albertoni, E. Marra, L. Luberto, C. Viollet, L. G. Spagnoli, A. Riccio, , R. De Santis

The paper shows that scFv76 antibody neutralizes multiple SARS-CoV-2 variants and reduces lung damage in mice when delivered via aerosol.

bioRxiv · May 27, 2022Microbiology

Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter

T. Schulte, A. Chaves-Sanjuan, G. Mazzini, V. Speranzini, F. Lavatelli, F. Ferri, C. Palizzotto, M. Mazza, P. Milani, M. Nuvolone, A.-C. Vogt, G. Palladini, G. Merlini, M. Bolognesi, S. Ferro, , S. Ricagno

The paper presents a cryo-EM structure of AA amyloid fibrils from a cat with renal failure, revealing a distinct amyloid fold despite high sequence homology to human and mouse SAA.

bioRxiv · May 9, 2022Biophysics