Author

A. Paiardini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Tramonti· 3 shared R. Contestabile· 3 shared A. Paone· 2 shared C. Ascanelli· 2 shared C. Lindon· 2 shared D. Boi· 2 shared D. Capelli· 2 shared F. Cutruzzola· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

A. Tramonti

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

THE RIBOREGULATION MECHANISM OF HUMAN SERINE HYDROXYMETHYLTRANSFERASE IS ROOTED IN AN ALLOSTERIC SWITCH

S. Spizzichino, F. Di Fonzo, C. Marabelli, A. Tramonti, A. Chaves-Sanjuan, A. Parroni, G. Boumis, F. R. Liberati, A. Paone, L. C. Montemiglio, M. Ardini, A. J. Jakobi, A. Bharadwaj, P. Swuec, G. G. Tartaglia, , F. Cutruzzola

This study identifies an allosteric RNA switch mechanism regulating SHMT1 activity, revealing structural elements critical for RNA binding and implications for RNA-based therapies.

bioRxiv · Mar 17, 2023Biochemistry

A short ERAP2 that binds IRAP is expressed in macrophages independently from gene variation

B. Mattorre, S. Caristi, S. Donato, E. Volpe, M. Faiella, A. Paiardini, R. Sorrentino, F. Paladini

The paper identifies a short ERAP2 isoform expressed in macrophages that binds IRAP, independent of gene variation, and suggests a functional role in specialized cells.

bioRxiv · Mar 7, 2022Biochemistry

Revisiting degron motifs in human AURKA required for its targeting by APC/C-FZR1

C. Lindon, A. A. Abdelbaki, C. Ascanelli, C. Okoye, H. B. Akman, G. Janson, M.-w. Min, C. Marcozzi, A. Hagting, R. Grant, M. De Luca, I. A. Asteriti, G. Guarguaglini, A. Paiardini

This study redefines AURKA degron motifs, showing the N-terminal A-box functions as a D-box and the C-terminal D-box is not a degron but a structural motif essential for AURKA's active conformation.

bioRxiv · Jan 31, 2022Cell Biology

A Focused Small-Molecule Screen Identifies PHA-680626 as an Amphosteric Inhibitor Disrupting the Interaction between Aurora-A and N-Myc

F. Souvalidou, D. Boi, R. Montanari, F. Polverino, G. Marini, D. Capelli, G. Pochetti, R. Contestabile, D. Trisciuoglio, A. Tramonti, P. Carpinelli, C. Ascanelli, C. Lindon, A. De Leo, R. Di Santo, , A. Paiardini

This study identifies PHA-680626 as an amphosteric inhibitor that disrupts the AURKA/N-Myc interaction, reducing N-Myc levels and cell viability in neuroblastoma cells.

bioRxiv · Mar 10, 2021 · PreprintCancer Biology

Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex

S. Spizzichino, D. Boi, G. Boumis, R. Lucchi, F. R. Liberati, D. Capelli, R. Montanari, G. Pochetti, A. Paone, S. Rinaldo, R. Contestabile, A. Paiardini, A. Tramonti, G. Giardina, F. Cutruzzola

This study investigates the cytosolic localization and in vitro assembly of the human de novo thymidylate synthesis complex, suggesting its role extends beyond dTMP synthesis.

bioRxiv · Dec 23, 2020Biochemistry