Author

S. Spizzichino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Paiardini· 2 shared A. Paone· 2 shared A. Tramonti· 2 shared F. Cutruzzola· 2 shared F. R. Liberati· 2 shared G. Boumis· 2 shared G. Giardina· 2 shared R. Contestabile· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. Paiardini

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2 papers

Recent·Most cited

THE RIBOREGULATION MECHANISM OF HUMAN SERINE HYDROXYMETHYLTRANSFERASE IS ROOTED IN AN ALLOSTERIC SWITCH

S. Spizzichino, F. Di Fonzo, C. Marabelli, A. Tramonti, A. Chaves-Sanjuan, A. Parroni, G. Boumis, F. R. Liberati, A. Paone, L. C. Montemiglio, M. Ardini, A. J. Jakobi, A. Bharadwaj, P. Swuec, G. G. Tartaglia, , F. Cutruzzola

This study identifies an allosteric RNA switch mechanism regulating SHMT1 activity, revealing structural elements critical for RNA binding and implications for RNA-based therapies.

bioRxiv · Mar 17, 2023Biochemistry

Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex

S. Spizzichino, D. Boi, G. Boumis, R. Lucchi, F. R. Liberati, D. Capelli, R. Montanari, G. Pochetti, A. Paone, S. Rinaldo, R. Contestabile, A. Paiardini, A. Tramonti, G. Giardina, F. Cutruzzola

This study investigates the cytosolic localization and in vitro assembly of the human de novo thymidylate synthesis complex, suggesting its role extends beyond dTMP synthesis.

bioRxiv · Dec 23, 2020Biochemistry