Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
F. Vascon, S. De Felice, M. Gasparotto, S. Huber, C. Catalano, M. Chinellato, A. Grinzato, F. Filippini, L. Maso, A. J. Jakobi, L. Cendron
This study reveals the structural basis of RecA-LexA interaction in Pseudomonas aeruginosa, showing how RecA triggers LexA cleavage and inactivation, which is critical for the SOS response.
bioRxiv · Mar 22, 2024Biochemistry
T. I. Kuhm, L. Gross, C. de Agrela Pinto, S. T. Huber, C. Taisne, E. A. Giannopoulou, E. Pardon, J. Steyaert, S. J. Tans, A. J. Jakobi
This study determines the cryo-EM structure of human GBP1 dimer and coatomer assemblies, revealing how nucleotide binding and hydrolysis drive membrane targeting and coatomer formation.
bioRxiv · Mar 28, 2023Biophysics
S. Spizzichino, F. Di Fonzo, C. Marabelli, A. Tramonti, A. Chaves-Sanjuan, A. Parroni, G. Boumis, F. R. Liberati, A. Paone, L. C. Montemiglio, M. Ardini, A. J. Jakobi, A. Bharadwaj, P. Swuec, G. G. Tartaglia, , F. Cutruzzola
This study identifies an allosteric RNA switch mechanism regulating SHMT1 activity, revealing structural elements critical for RNA binding and implications for RNA-based therapies.
bioRxiv · Mar 17, 2023Biochemistry
W. Wang, A. J. Jakobi, Y.-l. Wu, J. J. Ries, S. Stallinga, B. Rieger
The paper uses particle fusion of single molecule localization microscopy data to determine the dimer structure of Nup96 in the Nuclear Pore Complex, showing 32 copies per pore.
bioRxiv · Oct 4, 2022 · PreprintCell Biology
S. T. Huber, D. Terwiel, W. H. Evers, D. Maresca, A. J. Jakobi
The paper determines the cryo-EM structure of gas vesicles from B. megaterium, revealing their self-assembly mechanism and structural features that enable buoyancy control.
bioRxiv · May 8, 2022Biophysics
R. Maan, L. Reese, V. A. Volkov, M. R. King, E. van der Sluis, N. Andrea, W. Evers, A. J. Jakobi, M. Dogterom
The paper shows that multivalent interactions enable motor-dependent protein accumulation at microtubule ends through disordered networks and liquid droplet formation in a reconstituted fission yeast system.
bioRxiv · Sep 14, 2021Cell Biology
S. T. Huber, E. Sarajlic, R. Huijink, F. Weis, W. H. Evers, A. J. Jakobi
This paper introduces nanofluidic chips for cryo-EM that enable reproducible ice thickness from picoliter samples, improving high-resolution structure determination.
bioRxiv · May 25, 2021Biophysics