Author

A. Purkiss

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Kjaer· 2 shared C. A. Moores· 1 shared C. S. Hill· 1 shared D. Joshi· 1 shared G. Romet-Lemonne· 1 shared I. Gori· 1 shared L. Cao· 1 shared L. Faivre· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

S. Kjaer

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Author profile →

2 papers

Recent·Most cited

Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

I. Gori, R. George, A. Purkiss, S. Strohbuecker, R. A. Randall, R. Ogrodowicz, V. Carmignac, L. Faivre, D. Joshi, S. Kjaer, C. S. Hill

This study shows that SGS mutations in SKI prevent its binding to phosphorylated SMAD2/3, leading to SKI stabilization and reduced TGF-β responses.

bioRxiv · Oct 7, 2020Biochemistry

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

O. von Loeffelholz, A. Purkiss, L. Cao, S. Kjaer, N. Kogata, G. Romet-Lemonne, M. Way, C. A. Moores

The paper determines cryo-EM structures of human Arp2/3 complexes with different ARPC5 isoforms to show how isoform variation affects complex activity.

Biology Open · Jan 1, 2020Peer-reviewedBiophysics