Author

C. A. Moores

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell signaling & trafficking· 7 Research Focus:cell type annotation· 4 Organism:plant (other)· 3 Assay:cryo-EM· 2 Research Focus:development & morphogenesis· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2

Frequent Co-Authors

R. Tewari· 5 shared J. Atherton· 4 shared A. A. Holder· 3 shared D. Brady· 3 shared D. J. P. Ferguson· 3 shared K. G. Le Roch· 3 shared M. Zeeshan· 3 shared S. Abel· 3 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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5 shared papersCell Biology

R. Tewari

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission

T. Liu, F. Shilliday, A. D. Cook, R. Tewari, C. J. Sutherland, A. J. Roberts, C. A. Moores

This study investigates the molecular mechanism of Plasmodium kinesin-8B, showing its role in male gamete development and parasite transmission through ATP-dependent microtubule interactions and structural adaptations.

bioRxiv · Feb 11, 2022Biochemistry

Visualising the cytoskeletal machinery in neuronal growth cones using cryo-electron tomography

J. Atherton, M. Stouffer, F. Francis, C. A. Moores

The paper uses cryo-electron tomography to visualize the 3D subcellular architecture of neuronal growth cones, revealing distinct F-actin and microtubule structures and their molecular modulation.

bioRxiv · Aug 6, 2021Cell Biology

Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle

M. Zeeshan, R. Rashpa, D. J. P. Ferguson, S. Abel, Z. Chahine, D. Brady, s. vaughan, C. A. Moores, K. G. Le Roch, M. Brochet, A. A. Holder, R. Tewari

The paper identifies key kinesins involved in the malaria parasite life cycle in mammalian and mosquito hosts, showing kinesin-13 is essential for growth in mammals while others are critical for mosquito transmission.

bioRxiv · May 26, 2021Cell Biology

Lattice defects induced by microtubule-stabilizing agents exert a long-range effect on microtubule growth by promoting catastrophes

A. Rai, T. Liu, E. A. Katrukha, J. Estevez-Gallego, I. Paterson, F. Diaz, L. C. Kapitein, C. A. Moores, A. Akhmanova

This study shows that microtubule-stabilizing agents induce lattice defects that cause long-range catastrophes in microtubule growth.

bioRxiv · Feb 11, 2021Cell Biology

Molecular mechanism of a parasite kinesin motor and implications for its inhibition

A. D. Cook, A. Roberts, J. Atherton, R. Tewari, M. Topf, C. A. Moores

This study characterizes the molecular mechanism of Plasmodium falciparum kinesin-5 (PfK5) and identifies structural features that could enable selective inhibition of this parasite's motor.

bioRxiv · Jan 26, 2021Biophysics

The mechanism of selective kinesin inhibition by kinesin binding protein.

J. Atherton, J. J. A. Hummel, N. Olieric, J. Locke, A. Pena, S. S. Rosenfeld, M. O. Steinmetz, C. C. Hoogenraad, C. A. Moores

This study identifies how kinesin binding protein selectively inhibits specific kinesins by structurally distorting their motor domains and blocking microtubule attachment.

bioRxiv · Jul 17, 2020 · PreprintBiochemistry

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

O. von Loeffelholz, A. Purkiss, L. Cao, S. Kjaer, N. Kogata, G. Romet-Lemonne, M. Way, C. A. Moores

The paper determines cryo-EM structures of human Arp2/3 complexes with different ARPC5 isoforms to show how isoform variation affects complex activity.

Biology Open · Jan 1, 2020Peer-reviewedBiophysics

Pseudo-repeats in doublecortin make distinct mechanistic contributions to microtubule regulation

S. W. Manka, C. A. Moores

This study uses cryo-EM and microscopy to show how different domains of doublecortin regulate microtubule nucleation and stabilization through distinct mechanisms.

bioRxiv · Oct 17, 2019Biophysics

Kinesin-8B controls basal body function and flagellum formation and is key to malaria parasite transmission

M. Zeeshan, D. J. P. Ferguson, S. Abel, A. Burrrell, E. Rea, D. Brady, E. Daniel, M. Delves, S. Vaughan, A. A. Holder, K. G. Le Roch, C. A. Moores, R. Tewari

This study identifies kinesin-8B's role in malaria parasite flagellum formation and transmission by analyzing its localization and function during gamete development.

bioRxiv · Jul 2, 2019Cell Biology

Plasmodium Kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission

M. Zeeshan, F. Shilliday, T. Liu, S. Abel, T. Mourier, D. J. P. Ferguson, E. Rea, R. R. Stanway, M. Roques, D. Williams, E. Daniel, D. Brady, A. J. Roberts, A. A. Holder, A. Pain, , R. Tewari

This study identifies Plasmodium Kinesin-8X as essential for endomitotic division during oocyst development and parasite transmission.

bioRxiv · Jun 29, 2019Cell Biology

Mitotic phosphorylation by Nek6 and Nek7 reduces microtubule affinity of EML4 to alter spindle dynamics and promote chromosome congression

A. M. Fry, R. Adib, J. M. Montgomery, J. Atherton, L. O'Regan, M. Richards, K. R. Straatman, D. Roth, A. Straube, R. Bayliss, C. A. Moores

bioRxiv · Nov 9, 2018Cell Biology