A. R. Hoover

Single-cell transcriptomics reveals that tumor-infiltrating natural killer cells are activated by localized ablative immunotherapy and share anti-tumor signatures induced by immune checkpoint inhibitors

This study shows that localized ablative immunotherapy activates NK cells and shares anti-tumor gene signatures with immune checkpoint inhibitors, correlating with improved patient survival.

A novel biopolymer for mucosal adjuvant against respiratory pathogens

This study evaluates a novel biopolymer, GC, as a nasal mucosal adjuvant for respiratory vaccines, showing improved immune response and survival in mice compared to Addavax.

A novel biopolymer synergizes type I IFN and IL-1β production through STING

This study shows that GC activates STING and enhances type I IFN and IL-1β production, promoting antitumor and antiviral immune responses.

N-dihydrogalactochitosan reduces mortality in a lethal mouse model of SARS-CoV-2

N-dihydrogalactochitosan reduces mortality and morbidity in a lethal SARS-CoV-2 mouse model by lowering viral load and improving survival.

ScRNA-seq reveals tumor microenvironment remodeling induced by local intervention-based immunotherapy

This study uses scRNA-seq to show that LIT induces proinflammatory cytokine signaling and immune cell activation in tumor microenvironments of MMTV-PyMT mice.