A. L. Welm

Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs

Low-affinity CAR T cells exhibit reduced trogocytosis, preventing fratricide and antigen-negative tumor escape while preserving anti-tumor activity

PDXNet Portal: Patient-Derived Xenograft model, data, workflow, and tool discovery

The paper introduces the PDXNet Portal, a centralized resource for PDX models and data, offering analysis workflows and facilitating cancer research collaboration.

Laterally transferred macrophage mitochondria acts as a signaling source promoting cancer cell proliferation

The paper shows that dysfunctional macrophage mitochondria transferred to cancer cells promote proliferation via ROS-induced ERK signaling.

A breast cancer patient-derived xenograft and organoid platform for drug discovery and precision oncology

The paper develops patient-derived xenografts and organoids for breast cancer to enable drug screening and precision oncology, showing efficacy of an FDA-approved drug in a clinical case.

ScRNA-seq reveals tumor microenvironment remodeling induced by local intervention-based immunotherapy

This study uses scRNA-seq to show that LIT induces proinflammatory cytokine signaling and immune cell activation in tumor microenvironments of MMTV-PyMT mice.

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.