ImmunologybioRxivPreprint
A ubiquitin-independent proteasome pathway controls the CARD8 inflammasome
J. C. Hsiao, A. R. Neugroschl, A. J. Chui…·D. A. Bachovchin
This study identifies a ubiquitin-independent proteasome pathway that degrades the CARD8 N-terminal fragment, releasing the inflammatory C-terminal fragment and activating the inflammasome.
DOI 10.1101/2022.03.22.485305