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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
H.-C. Huang, I. Nowak, V. Lobo, D. F. Besavilla, K. Schon, J. O. Westholm, C. Fernandez, A. A. Patel, C. Wiel, V. I. Sayin, D. G. Anastasakis, D. Angeletti, A. A. Sarshad
This study shows that influenza A virus exploits nuclear RNAi by inducing AGO2 accumulation and silencing type-I interferon genes, and that arsenic trioxide can counteract this effect.
bioRxiv · Mar 7, 2024 · PreprintBiochemistry
C. T. Inglut, J. A. Quinlan, R. W. Robey, J. R. Thomas, J. R. Walker, W. Zhou, H.-C. Huang, M. M. Gottesman
The paper identifies NanoLuciferase substrates transported by human and zebrafish ABC transporters at the BBB, aiding in the development of a transgenic zebrafish model to detect BBB disruptors.
bioRxiv · Oct 20, 2023 · PreprintPharmacology & Toxicology
V. Lobo, I. Nowak, C. Fernandez, A. I. Correa Muler, J. O. Westholm, H.-C. Huang, I. Fabrik, H. T. Huynh, E. Shcherbinina, M. Poyraz, A. Hartlova, D. Benhalevy, D. Angeletti, A. A. Sarshad
This study shows that loss of Lamin A causes AGO2 to move into the nucleus, impairing RNAi and increasing oncogenic miRNA expression in cancer cells.
bioRxiv · Jun 5, 2023Biochemistry
H.-C. Huang, T.-Y. Wang, J. Rousseau, M. Mungaray, C. Michaud, C. Plaisier, Z. B. Chen, K.-C. Wang
This paper develops a biomimetic nanodrug targeting YAP/TAZ in atherosclerotic plaques, showing reduced plaque development in mice with minimal off-target effects.
bioRxiv · Apr 24, 2023 · PreprintBioengineering
B. J. A. Magoling, A. Y.-T. Wu, Y.-J. Chen, W. W.-T. Wong, S. T.-Y. Chuo, H.-C. Huang, Y.-C. Sung, H.-T. Hsieh, P. Huang, K.-Z. Lee, K.-W. Huang, R.-H. Chen, Y. Chen, C. P. Lai
This study identifies distinct in vivo properties and functions of large and small extracellular vesicles in breast cancer, showing their differential biodistribution and tumorigenic potential.
bioRxiv · Sep 28, 2022 · PreprintCancer Biology
Q. Wang, J. Hsiao, N. Yardeny, H.-C. Huang, C. M. O'Mara, E. L. Orth-He, D. P. Ball, D. A. Bachovchin
This study identifies chemical probes that induce reductive stress and shows that reductive stress and peptide accumulation together strongly activate NLRP1 and CARD8 inflammasomes.
bioRxiv · Mar 22, 2022Immunology
J. C. Hsiao, A. R. Neugroschl, A. J. Chui, C. Y. Taabazuing, A. R. Griswold, Q. Wang, H.-C. Huang, E. L. Orth-He, D. P. Ball, G. Hiotis, D. A. Bachovchin
This study identifies a ubiquitin-independent proteasome pathway that degrades the CARD8 N-terminal fragment, releasing the inflammatory C-terminal fragment and activating the inflammasome.
bioRxiv · Mar 22, 2022 · PreprintImmunology
E. L. Orth-He, H.-C. Huang, S. D. Rao, Q. Wang, Q. Chen, C. M. O'Mara, A. J. Chui, M. Saoi, A. R. Griswold, A. Bhattacharjee, D. P. Ball, J. R. Cross, D. A. Bachovchin
This study identifies cytosolic peptide accumulation as a danger signal that activates NLRP1 and CARD8 inflammasomes by promoting NT degradation and disrupting DPP9-mediated sequestration of CT fragments.
bioRxiv · Mar 22, 2022 · PreprintImmunology
F. Pan, S.-X. Yu, X. Wang, H.-C. Huang, Z.-Y. Cai, J.-M. Wang, S.-Y. Lin, Y.-L. Gao, E.-M. Li, L.-Y. Xu
The paper characterizes epigenetic alterations in esophageal cancer using whole-genome bisulfite sequencing and identifies novel clusters and molecular features in two subtypes.
bioRxiv · Dec 5, 2021 · PreprintCancer Biology
T.-A. Zhou, H.-P. Hsu, Y.-H. Tu, H.-K. Cheng, C.-Y. Lin, N.-J. Chen, J.-W. Tsai, E. A. Robey, H.-C. Huang, C.-L. Hsu, I. L. Dzhagalov
This study identifies two distinct thymic macrophage populations with different locations and origins using single-cell RNA sequencing and genetic fate mapping.
bioRxiv · Nov 4, 2021Immunology
P.-L. Lai, T.-C. Chen, C.-Y. Feng, H. Lin, N. Wu, Y. Chen, M. Hsiao, J. Lu, H.-C. Huang
This study develops a sphere-forming assay to isolate a malignant subpopulation from a CRC cell line and identifies DPEP1 as a prognostic biomarker.
bioRxiv · Mar 15, 2019Cancer Biology