Author

C. Y. Taabazuing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. R. Griswold· 2 shared D. A. Bachovchin· 2 shared D. P. Ball· 2 shared S. Shin· 2 shared A. J. Chui· 1 shared A. R. Neugroschl· 1 shared B. M. Discher· 1 shared C. E. Odunze· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

A. R. Griswold

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4 papers

Recent·Most cited

The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspases

P. M. Exconde, C. Hernandez-Chavez, M. B. Bray, J. L. Lopez, T. Srivastava, M. S. Egan, J. Zhang, S. Shin, B. M. Discher, C. Y. Taabazuing

This study identifies that the tetrapeptide sequence of IL-1β regulates its cleavage by non-canonical inflammasomes, revealing a mechanism for inflammation control.

bioRxiv · Feb 16, 2023 · PreprintImmunology

Noncanonical inflammasome assembly requires caspase-11 catalytic activity and intra-molecular autoprocessing

D. C. Akuma, D. Grubaugh, C. E. Odunze, S. Shin, C. Y. Taabazuing, I. E. Brodsky

This study shows that Casp11 catalytic activity and autoprocessing are required for noncanonical inflammasome assembly and LPS-induced speck formation in macrophages.

bioRxiv · Sep 21, 2022Immunology

A ubiquitin-independent proteasome pathway controls the CARD8 inflammasome

J. C. Hsiao, A. R. Neugroschl, A. J. Chui, C. Y. Taabazuing, A. R. Griswold, Q. Wang, H.-C. Huang, E. L. Orth-He, D. P. Ball, G. Hiotis, D. A. Bachovchin

This study identifies a ubiquitin-independent proteasome pathway that degrades the CARD8 N-terminal fragment, releasing the inflammatory C-terminal fragment and activating the inflammasome.

bioRxiv · Mar 22, 2022 · PreprintImmunology

Human caspase-1 autoproteolysis is required for ASC-dependent and -independent inflammasome activation

D. P. Ball, C. Y. Taabazuing, A. R. Griswold, E. L. Orth, S. D. Rao, I. B. Kotliar, D. C. Johnson, D. A. Bachovchin

This study shows that pro-caspase-1 autoproteolysis is required for both ASC-dependent and -independent inflammasome activation in human cells.

bioRxiv · Jun 24, 2019 · PreprintImmunology