Author

J. C. Hsiao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Assay:protein structure· 1

Frequent Co-Authors

D. A. Bachovchin· 3 shared A. R. Griswold· 2 shared D. P. Ball· 2 shared Q. Wang· 2 shared A. Casadevall· 1 shared A. J. Chui· 1 shared A. R. Neugroschl· 1 shared A. Wallace· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

D. A. Bachovchin

Mutual co-authors in cluster

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4 papers

Recent·Most cited

The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond

M. B. Geeson, J. C. Hsiao, L. P. Tsamouri, D. P. Ball, D. A. Bachovchin

This study identifies a transient disulfide bond between NLRP1 and oxidized TRX1, revealing how NLRP1 senses cellular redox state to regulate inflammasome formation.

bioRxiv · Sep 27, 2023Immunology

Fc-engineered antibodies leverage neutrophils to drive control of Mycobacterium tuberculosis

E. B. Irvine, J. M. Peters, R. Lu, P. S. Grace, J. Sixsmith, A. Wallace, M. Schneider, S. Shin, W. Karpinski, J. C. Hsiao, E. van Woudenbergh, A. Casadevall, B. D. Bryson, L. Cavacini, G. Alter, S. M. Fortune

This study uses Fc-engineered antibodies to enhance Mtb control by leveraging neutrophils, showing restrictive Fc variants improve neutrophil survival and antimicrobial activity in a human whole blood model.

bioRxiv · May 1, 2022 · PreprintImmunology

A ubiquitin-independent proteasome pathway controls the CARD8 inflammasome

J. C. Hsiao, A. R. Neugroschl, A. J. Chui, C. Y. Taabazuing, A. R. Griswold, Q. Wang, H.-C. Huang, E. L. Orth-He, D. P. Ball, G. Hiotis, D. A. Bachovchin

This study identifies a ubiquitin-independent proteasome pathway that degrades the CARD8 N-terminal fragment, releasing the inflammatory C-terminal fragment and activating the inflammasome.

bioRxiv · Mar 22, 2022 · PreprintImmunology

Structural mechanism of CARD8 regulation by DPP9

H. Sharif, L. R. Hollingsworth, A. R. Griswold, J. C. Hsiao, Q. Wang, D. A. Bachovchin, H. Wu

This study reveals how DPP9 regulates CARD8 by forming a ternary complex and shows that DPP9 inhibitors activate CARD8 inflammasomes through two distinct mechanisms.

bioRxiv · Jan 13, 2021Immunology