Author

G. Hiotis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

A. J. Chui· 1 shared A. R. Griswold· 1 shared A. R. Neugroschl· 1 shared C. Hyland· 1 shared C. Y. Taabazuing· 1 shared D. A. Bachovchin· 1 shared D. P. Ball· 1 shared E. L. Orth-He· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperImmunology

A. J. Chui

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack

S. Yang, G. Hiotis, Y. Wang, J. Chen, J.-h. Wang, M. Kim, E. L. Reinherz, T. Walz

The paper investigates HIV-1 spike protein dynamics using cryo-EM and simulations, showing how tilting exposes the MPER to antibody attack and alters membrane fusion.

bioRxiv · May 9, 2022Biophysics

A ubiquitin-independent proteasome pathway controls the CARD8 inflammasome

J. C. Hsiao, A. R. Neugroschl, A. J. Chui, C. Y. Taabazuing, A. R. Griswold, Q. Wang, H.-C. Huang, E. L. Orth-He, D. P. Ball, G. Hiotis, D. A. Bachovchin

This study identifies a ubiquitin-independent proteasome pathway that degrades the CARD8 N-terminal fragment, releasing the inflammatory C-terminal fragment and activating the inflammasome.

bioRxiv · Mar 22, 2022 · PreprintImmunology

Impaired Cx43 gap junction endocytosis causes cardiovascular defects in zebrafish

C. Hyland, M. Mfarej, G. Hiotis, S. Lancaster, N. Novak, M. K. Iovine, M. M. Falk

This study shows that impaired Cx43 gap junction endocytosis in zebrafish leads to cardiovascular defects including arrhythmias and heart malformations.

bioRxiv · Mar 7, 2021Cell Biology