Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme)
H. Hashimoto, L. Kafkova, A. Raczkowski, K. D. Jordan, L. K. Read, E. W. Debler
This paper reports the crystal structure of a Trypanosoma brucei PRMT1 enzyme-prozyme heterotetramer, revealing how the prozyme stabilizes the enzyme and enables catalysis through structural and functional interactions.
bioRxiv · Sep 19, 2019Biochemistry