Author

O. S. Andersen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 2 Assay:electrophysiology· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Organism:fungi (other)· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

R. Rusinova· 4 shared T. Peyear· 2 shared A. Accardi· 1 shared A. Beyder· 1 shared A. D. White· 1 shared A. Di Lorenzo· 1 shared A. R. Watkins· 1 shared A. Raczkowski· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBiophysics

R. Rusinova

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

R. T. Eastman, R. Rusinova, K. F. Herold, X.-P. Huang, P. Dranchak, T. C. Voss, S. Rana, J. H. Shrimp, A. D. White, H. C. Hemmings, B. L. Roth, J. Inglese, O. S. Andersen, J. L. Dahlin

This study shows ivermectin reduces SARS-CoV-2 viral burden in vitro but at concentrations that also cause cytotoxicity, suggesting its antiviral effect may be due to nonspecific membrane perturbation rather than specific antiviral activity.

bioRxiv · Oct 23, 2023 · PreprintPharmacology & Toxicology

Capsaicin alters human NaV1.5 mechanosensitivity

L. M. Cowan, P. R. Strege, R. Rusinova, O. S. Andersen, A. Beyder, G. Farrugia

This study shows capsaicin reduces NaV1.5 mechanosensitivity in human cells by blocking force-induced changes in sodium current parameters and voltage-dependent behavior.

bioRxiv · Jul 13, 2021 · PreprintBiophysics

Mechanism and effects of the skeletal muscle Nav1.4 inhibition by cannabidiol

M.-R. Ghovanloo, K. Choudhury, T. S. Bandaru, M. A. Fouda, K. Rayani, R. Rusinova, T. Phaterpekar, K. Nelkenbrecher, A. R. Watkins, D. Poburko, J. Thewalt, O. S. Andersen, L. Delemotte, S. J. Goodchild, P. Ruben

This study investigates how cannabidiol inhibits Nav1.4 channels in skeletal muscle by modulating membrane elasticity and directly interacting with the channel pore.

bioRxiv · Jun 30, 2020Biophysics

Cryo-EM structures reveal bilayer remodeling during Ca2+ activation of a TMEM16 scramblase

M. E. Falzone, J. Rheinberger, B.-C. Lee, T. Peyear, L. Sasset, A. Raczkowski, E. Eng, A. Di Lorenzo, O. S. Andersen, C. M. Nimigean, A. Accardi

The paper presents cryo-EM structures of a fungal TMEM16 scramblase showing Ca2+-induced conformational changes and membrane reorganization.

bioRxiv · Nov 5, 2018Biochemistry

Gramicidin increases lipid flip-flop in symmetric and asymmetric lipid vesicles

M. Doktorova, F. A. Heberle, D. Marquardt, R. Rusinova, L. Sanford, T. Peyear, J. Katsaras, G. W. Feigenson, H. Weinstein, O. S. Andersen

This study shows gramicidin increases lipid flip-flop in both symmetric and asymmetric lipid vesicles through concentration-dependent mechanisms.

bioRxiv · Aug 2, 2018Biophysics