Author

M. E. Falzone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein structure prediction· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:fungi (other)· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Accardi· 2 shared R. MacKinnon· 2 shared A. C. W. Pike· 1 shared A. Chu· 1 shared A. Di Lorenzo· 1 shared A. Raczkowski· 1 shared A. Tessitore· 1 shared B.-C. Lee· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

A. Accardi

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Author profile →

4 papers

Recent·Most cited

The mechanism of Gαq regulation of PLCβ3-catalyzed PIP2 hydrolysis.

M. E. Falzone, R. MacKinnon

This paper shows Gq increases PLCβ3 catalytic rate and structures reveal G proteins regulate PLCβ3 via separate mechanisms, leading to a product rule of co-stimulation.

bioRxiv · Aug 29, 2023 · PreprintBiophysics

Gβγ Activates PIP2 Hydrolysis by Recruiting and Orienting PLCβ on the Membrane Surface

M. E. Falzone, R. MacKinnon

This study shows Gβγ activates PLCβ3 by recruiting and orienting it on the membrane, increasing catalytic efficiency and reducing background activity.

bioRxiv · Dec 20, 2022 · PreprintBiophysics

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

S. R. Bushell, A. C. W. Pike, M. E. Falzone, N. J. G. Rorsman, C. M. Ta, R. A. Corey, T. D. Newport, C. A. Shintre, A. Tessitore, A. Chu, Q. Wang, L. Shrestha, S. Mukhopadhyay, J. D. Love, N. A. Burgess-Brown, , E. P. Carpenter

This study identifies TMEM16K as an ER-resident calcium-regulated lipid scramblase and elucidates its structural basis for lipid scrambling and inactivation.

bioRxiv · Dec 12, 2018Biochemistry

Cryo-EM structures reveal bilayer remodeling during Ca2+ activation of a TMEM16 scramblase

M. E. Falzone, J. Rheinberger, B.-C. Lee, T. Peyear, L. Sasset, A. Raczkowski, E. Eng, A. Di Lorenzo, O. S. Andersen, C. M. Nimigean, A. Accardi

The paper presents cryo-EM structures of a fungal TMEM16 scramblase showing Ca2+-induced conformational changes and membrane reorganization.

bioRxiv · Nov 5, 2018Biochemistry