Structural and functional elucidation of NF-κB signaling by the p75 neurotrophin receptor through recruitment of TRADD
N. Zhang, L. Kisiswa, A. Ramanujan, Z. Li, E. W. Sim, W. Yuan, C. F. Ibanez, Z. LIN
This study determines the structure of the p75NTR-DD/TRADD-DD complex and shows TRADD recruitment regulates NF-κB signaling and cell survival in cerebellar granule neurons.
bioRxiv · Feb 7, 2021 · PreprintBiophysics