C. F. Ibanez

Impaired migration and metastatic spread of human melanoma by a novel small molecule targeting the transmembrane domain of death receptor p75NTR

This study identifies a small molecule that inhibits melanoma migration and metastasis by targeting the transmembrane domain of p75NTR, showing promise for cancer treatment.

Activin receptor ALK4 promotes adipose tissue hyperplasia by suppressing differentiation of adipocyte precursors

This study identifies ALK4's role in promoting adipose tissue hyperplasia by inhibiting adipocyte precursor differentiation during obesity.

Evidence for the equilibrium between monomers and dimers of the death domain of the p75 neurotrophin receptor

The paper provides evidence that the death domain of the p75 neurotrophin receptor exists in equilibrium between monomeric and dimeric forms in solution.

Structural and functional elucidation of NF-κB signaling by the p75 neurotrophin receptor through recruitment of TRADD

This study determines the structure of the p75NTR-DD/TRADD-DD complex and shows TRADD recruitment regulates NF-κB signaling and cell survival in cerebellar granule neurons.

Sustained anti-obesity effects of life-style change and anti-inflammatory interventions after conditional inactivation of the activin receptor ALK7

This study shows that combining ALK7 inhibition with lifestyle or anti-inflammatory interventions leads to sustained weight loss in obese mice, even under high caloric intake.

Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7

This study identifies ALK7 as a regulator of brown adipose tissue adaptation to nutrient stress by suppressing catabolic responses during fasting.