Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice
F. Singh, A. R. Prescott, G. Ball, A. Reith, I. Ganley
This study shows that the LRRK2 G2019S mutation impairs mitophagy in mice, and that LRRK2 inhibitors can rescue this defect, suggesting a potential therapy for Parkinson's disease.
bioRxiv · Dec 7, 2020Cell Biology