A. R. Prescott

PINK1 regulated mitophagy is evident in skeletal muscles

The paper shows that PINK1 loss reduces mitophagy in skeletal muscle, which is restored by a POLGD257A mutation, highlighting skeletal muscle as a model for studying PINK1-dependent mitophagy.

Golgi-IP, a novel tool for multimodal analysis of Golgi molecular content

This paper introduces Golgi-IP, a method to isolate and analyze the human Golgi's proteome, metabolome, and lipidome, revealing novel components and metabolic features.

Phase-separated stress granules and processing bodies are compromised in Myotonic Dystrophy Type 1

This study shows that stress granules and processing bodies are disrupted in DM1 cell models due to CUGexp RNA, affecting their structure and dynamics.

Global ubiquitylation analysis of mitochondria in primary neurons identifies physiological Parkin targets following activation of PINK1

The paper identifies 49 PINK1-dependent ubiquitylated proteins in mouse neurons and develops a resource to visualize mitochondrial ubiquitin sites.

Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice

This study shows that the LRRK2 G2019S mutation impairs mitophagy in mice, and that LRRK2 inhibitors can rescue this defect, suggesting a potential therapy for Parkinson's disease.

Ultrasound Mediated Delivery of Quantum Dots from a Capsule Endoscope to the Gastrointestinal Wall

This paper demonstrates a capsule device that uses focused ultrasound and microbubbles to deliver fluorescent markers through the mucus layer of the porcine small intestine.

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

This study identifies novel SGK3 substrates, including endosomal proteins, through phosphoproteomic screens and shows SGK3 specifically phosphorylates these proteins at sites distinct from Akt.

A conserved ATG2-GABARAP interaction is critical for phagophore closure

This study identifies a conserved ATG2-GABARAP interaction critical for phagophore closure, showing that it is essential for autophagy, while the ATG2-WIPI4 interaction is not.

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

This study identifies FAM83D as a scaffold that recruits CK1α to the mitotic spindle, ensuring proper spindle positioning and timely cell division.

Bifunctionality Of A Biofilm Matrix Protein Controlled By Redox State

This study shows that BslA, a biofilm matrix protein in Bacillus subtilis, has two distinct functions controlled by redox state and dimerization.