Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase
I. Singh, F. Li, E. Fink, I. Chau, A. Li, A. Rodriguez-Hernandez, I. Glenn, F. J. Zapatero-Belinchon, M. Rodriguez, K. Devkota, Z. Deng, K. White, X. Wan, N. A. Tolmachova, Y. S. Moroz, , B. K. Shoichet
The paper identifies multiple inhibitors of SARS-CoV-2 Nsp14 N7-methyltransferase using docking strategies, with some showing sub-10 M potency and selectivity.
bioRxiv · Jan 12, 2023 · PreprintBiophysics