M. Rodriguez

MDM2 stabilization of Notch intracellular domain upon DNA damage plays a major role in non-small cell lung carcinoma response to platinum chemotherapy

This study identifies MDM2 stabilization of NICD in response to platinum chemotherapy in NSCLC, showing that targeting MDM2 and NICD improves survival and reduces tumor growth.

Adaptive gene loss in the common bean pan-genome during range expansion and domestication

This study identifies adaptive gene loss in common bean populations during range expansion and domestication, showing gene loss as a key adaptive trait.

Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

The paper identifies multiple inhibitors of SARS-CoV-2 Nsp14 N7-methyltransferase using docking strategies, with some showing sub-10 M potency and selectivity.

dsRNA-induced immunity targets plasmodesmata and is suppressed by viral movement proteins

This study shows dsRNA-induced immunity targets plasmodesmata by triggering callose deposition to restrict virus movement, which is suppressed by viral movement proteins.

Inflammation durably imprints memory CD4+ T cells

This study compares transcriptional and epigenetic differences in Spike-specific CD4+ T cell memory between individuals primed by SARS-CoV-2 infection versus mRNA vaccination.

Using Extracellular Vesicles Released by GDNF-transfected Macrophages for Therapy of Parkinson's Disease

This study uses GDNF-loaded extracellular vesicles from macrophages to treat Parkinson's disease, showing improved mobility and reduced neuroinflammation in mice.

Biomass formation and sugar release efficiency of Populus modified by altered expression of a NAC transcription factor

This study investigates the role of PdWND1B in Populus wood formation and biofuel conversion by over-expressing or silencing it, showing effects on biomass, cell wall composition, and sugar release efficiency.

Ing4-deficiency enhances HSC quiescence and confers resistance to inflammatory stress

This study shows that Ing4 deficiency increases HSC quiescence and protects against inflammatory stress by altering gene expression and cell cycle dynamics.

Elucidating the viral and host factors enabling the cross-species transmission of primate lentiviruses from simians to humans

This study compares the replicative fitness and pathogenicity of 26 primate lentiviruses in human and chimpanzee cells, finding SIVcpz has higher fitness and lower restriction in human cells than HIV-2 lineage strains.

Selective Vulnerability of Senescent Glioblastoma Cells to Bcl-XL Inhibition

This study identifies Bcl-XL inhibition as a selective vulnerability of senescent glioblastoma cells following radiation or TMZ treatment.

Impact of the radiated brain microenvironment on a panel of human patient-derived xenografts.

This study evaluates how the radiated brain microenvironment affects the growth of nine human glioblastoma cell lines, finding that some tumors grow faster while others grow slower in this environment.

ZIKA VIRUS INFECTION DURING PREGNANCY AND INDUCED BRAIN PATHOLOGY IN BECLIN1-DEFICIENT MOUSE MODEL

This study investigates the role of Beclin1 in ZIKV infection during pregnancy, showing growth impairments and brain pathology in offspring of Beclin1-deficient mice.

Non-Canonical Regulation of Phosphatidylserine Metabolism by a Phosphatidylinositol Transfer Protein and a Phosphatidylinositol 4-OH Kinase

The paper shows that Psd2-dependent phosphatidylethanomaine production in yeast relies on Psd2, Sfh4, and Stt4, with Sfh4 activating the pathway through a physical interaction rather than its PtdIns transfer activity.

Inhalation of marijuana affects Drosophila heart function

This study shows that vaporized marijuana reduces heart rate and increases contractility in Drosophila melanogaster without affecting calcium handling.