Author

I. Glenn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 4 Research Focus:drug response / drug discovery· 4 Assay:structural biology· 3 Organism:human· 2 Organism:virus· 2 Approach:diffusion model· 1 Approach:experimental assay· 1 Assay:protein structure· 1

Frequent Co-Authors

B. K. Shoichet· 4 shared J. J. Irwin· 4 shared Y. S. Moroz· 3 shared F. Liu· 2 shared I. Singh· 2 shared J. Lyu· 2 shared K. White· 2 shared X. Wan· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersBiophysics

B. K. Shoichet

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4 papers

Recent·Most cited

Structure-based discovery of positive allosteric modulators for the calcium sensing receptor

F. Liu, C.-G. Wu, C.-L. Tu, I. Glenn, J. Meyerowitz, A. L. Kaplan, J. Lyu, Z. Cheng, O. O. Tarkhanova, Y. S. Moroz, J. J. Irwin, W. Chang, B. K. Shoichet, G. Skiniotis

The paper uses structure-based virtual screening to identify novel CaSR PAMs with higher potency and reduced side effects compared to existing drugs.

bioRxiv · Dec 27, 2023 · PreprintBiophysics

Large library docking for cannabinoid-1 receptor agonists with reduced side effects

T. A. Tummino, C. Iliopoulos-Tsoutsouvas, J. M. Braz, E. S. O'Brien, R. M. Stein, V. Craik, N. K. Tran, S. Ganapathy, F. Liu, Y. Shiimura, F. Tong, T. C. Ho, D. S. Radchenko, Y. S. Moroz, S. R. Rosado, , B. K. Shoichet

The paper identifies a new cannabinoid-1 receptor agonist with reduced side effects through large library docking and experimental validation.

bioRxiv · Feb 27, 2023 · PreprintPharmacology & Toxicology

Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

I. Singh, F. Li, E. Fink, I. Chau, A. Li, A. Rodriguez-Hernandez, I. Glenn, F. J. Zapatero-Belinchon, M. Rodriguez, K. Devkota, Z. Deng, K. White, X. Wan, N. A. Tolmachova, Y. S. Moroz, , B. K. Shoichet

The paper identifies multiple inhibitors of SARS-CoV-2 Nsp14 N7-methyltransferase using docking strategies, with some showing sub-10 M potency and selectivity.

bioRxiv · Jan 12, 2023 · PreprintBiophysics

Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors

E. A. Fink, C. Bardine, S. Gahbauer, I. Singh, K. White, S. Gu, X. Wan, B. Ary, I. Glenn, J. O'Connell, H. O'Donnell, P. Fajtova, J. Lyu, S. Vigneron, N. J. Young, , C. S. Craik

The paper identifies novel non-covalent and covalent inhibitors of SARS-CoV-2 main protease through virtual docking and experimental validation.

bioRxiv · Jul 5, 2022Biophysics