Z. Deng

Promotion of RNF168-Mediated Nucleosomal H2A Ubiquitylation by Structurally-defined K63-Polyubiquitylated Linker Histone H1

This study develops a chemical synthesis method to create polyubiquitylated linker histone H1.0, revealing its role in enhancing RNF168-mediated H2A ubiquitylation through structural and biochemical analysis.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

Discovery of the First-in-class G9a/GLP PROTAC Degrader

This paper discovers a first-in-class PROTAC degrader for G9a/GLP, showing effective degradation and superior anticancer activity compared to existing inhibitors.

Activated STING in the thymus alters T cell development and selection leading to autoimmunity

This study shows STING activation in thymic epithelial cells disrupts T cell selection and promotes autoimmunity by altering interferon signaling and macroautophagy.

Reductive dehalogenation by diverse microbes is central to biogeochemical cycles in deep-sea cold seeps

The paper investigates reductive dehalogenation in deep-sea cold seeps, identifying diverse RDases and their ecological role in biogeochemical cycles.

Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.

Single-cell transcriptomics reveals cellular hierarchies and aberrant CTS contraction-mediated premature hair regression in androgenetic alopecia

This study uses single-cell transcriptomics to identify cellular hierarchies and CTS contraction as a driver of premature hair regression in AGA, showing ML-7 can improve hair growth.

Alteration in Gut Microbiome and Intestinal Barrier Function caused by Efavirenz versus Dolutegravir Treatments in Mice

This study compares the effects of EFV and DTG on gut microbiome and intestinal barrier function in mice, finding both drugs impair gut barrier integrity, with EFV causing more severe metabolic and structural changes.

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

The paper identifies two European bat MERS-related coronaviruses that use ACE2 as their receptor, revealing a distinct binding mode and host tropism determinants.

A chromosome-scale and haplotype-resolved genome assembly of tetraploid blackberry (Rubus L. subgenus Rubus Watson)

This paper presents a chromosome-scale, haplotype-resolved genome assembly for tetraploid blackberry, identifying candidate genes related to thornlessness and fruiting habit.

Dynamics of the epigenetic landscape during development and in response to drought stress in sorghum

This study identifies novel epigenomic features in sorghum, including H3K27me3 islands and the role of histone marks in regulating tissue-specific and stress-responsive genes.

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

This study identifies a molecular mechanism by which amyloplast sedimentation triggers LAZY protein relocalization to mediate gravity sensing in Arabidopsis.

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

The paper identifies multiple inhibitors of SARS-CoV-2 Nsp14 N7-methyltransferase using docking strategies, with some showing sub-10 M potency and selectivity.

Large-scale phylogenomics of aquatic bacteria reveal molecular mechanisms for adaptation to salinity

This study uses phylogenomic analysis of metagenome-assembled genomes to show that bacterial species rarely exist in multiple biomes and that cross-biome transitions involve proteome reorganization and gene content changes.

Comparative genomic analyses of Lactococcus garvieae isolated from bovine mastitis in China

This study characterizes Lactococcus garvieae isolates from bovine mastitis in China, identifying genetic diversity, antimicrobial resistance, virulence factors, and potential host adaptation.

A Modular Chemoenzymatic Approach to C14-Functionalized Steroids

This paper develops a modular chemoenzymatic method to synthesize diverse C14-functionalized steroids using a novel CYP14A enzyme and its variants.

Structural mechanism of leaflet-specific phospholipid modulation of a pentameric ligand-gated ion channel

The paper shows phosphatidylglycerol stabilizes the open state of ELIC by binding to a specific outer leaflet site, identified through structural and functional analyses.

A common mechanism of temperature-sensing in thermoTRP channels

This study identifies a common mechanism for temperature sensing in TRPM8 and TRPV1 thermoTRP channels through water-protein interaction changes.

Temporal and Spatial Resolution of a Protein Quake that Activates Hydrogen Tunneling in Soybean Lipoxygenase

This study investigates hydrogen tunneling in soybean lipoxygenase using X-ray and deuterium exchange experiments, revealing a protein quake mechanism linked to catalytic activation.

An open source 16-channel fluidics system for automating sequential fluorescent in situ hybridization (FISH)-based imaging

This paper introduces an open-source fluidics system for automating sequential FISH-based imaging, demonstrating its use in 14 rounds of hybridization on HeLa cells.

Editing the CsDMR6 Gene in Citrus Results in Resistance to the Bacterial Disease Citrus Canker

This study edits the CsDMR6 gene in citrus to confer resistance to citrus canker, showing significant reduction in disease symptoms and bacterial population.

The tRNA thiolation-mediated translational control is essential for plant immunity

This study identifies tRNA thiolation as essential for plant immunity by showing its role in regulating NPR1 translation and salicylic acid signaling in Arabidopsis.

A chromosome-level phased Citrus sinensis genome facilitates understanding Huanglongbing tolerance mechanisms at the allelic level in an irradiation induced mutant

The paper presents a chromosome-level phased genome of Valencia sweet orange, enabling allelic-level analysis of Huanglongbing tolerance in mutants.

Functional and evolutionary significance of unknown genes from uncultivated taxa

The paper identifies and analyzes novel protein families from uncultivated microbes, revealing their evolutionary significance and potential ecological roles.

Characterization of pyridomycin B reveals the formation of functional groups in antimycobacterial pyridomycin

This study characterizes pyridomycin B, a pyridomycin analogue, revealing that Pyr2 catalyzes ketoreduction and double bond formation in a unique energy-saving manner, contributing to the formation of functional groups in pyridomycin.

Mechanistic insights into dideoxygenation in gentamicin biosynthesis

The paper elucidates the dideoxygenation mechanism in gentamicin biosynthesis, showing how intermediates JI-20A and JI-20B are converted to gentamicin C complex through phosphorylation and PLP-dependent enzymatic reactions.

The first report and biological characteristics of Helcococcus ovis isolated from clinical bovine mastitis in a Chinese dairy herd

This study isolates and characterizes Helcococcus ovis from clinical bovine mastitis in China, showing its antimicrobial sensitivity and pathogenic potential in a murine model.

A Systematic and Consistent Assay for High-throughput Characterization of Stalk Quality in Sugarcane by Near-infrared Spectroscopy

This study develops a high-throughput method using near-infrared spectroscopy to assess sugarcane stalk quality, achieving high prediction accuracy with RPD values up to 6.3.

The Transcription Factor TEAD4 Enhances Lung Adenocarcinoma Malignancy through Enhancing PKM2 Mediated Glycolysis

This study shows TEAD4 and PKM2 are upregulated in LUAD and linked to poor prognosis, with TEAD4 promoting PKM2 transcription and glycolysis, suggesting targeting this axis could be a therapeutic strategy.