Prostaglandin F2α-induced TGFβ-PMEPA1 pathway is a critical mediator of epithelial plasticity and ovarian carcinoma progression.
A. Jimenez-Segovia, A. Mota, A. Rojo-Sebastian, B. Barrocal, A. Rynne-Vidal, M. L. Garcia-Bermejo, R. Gomez-Bris, L. J. A. C. Hawinkels, P. Sandoval, R. Garcia-Escudero, M. Lopez-Cabrera, G. Moreno-Bueno, M. Fresno, K. Stamatakis
This paper identifies PGF2α-induced TGFβ-PMEPA1 pathway as a driver of epithelial plasticity and ovarian cancer progression, with PMEPA1 as a therapeutic target and prognostic biomarker.
bioRxiv · Sep 18, 2018Cancer Biology