J. N. Hansen

Opposing roles of resident and infiltrating immune cells in the defence against Legionella longbeachae via IL-18R/IFN-γ/ROS axis

This study identifies opposing roles of tissue-resident alveolar macrophages and infiltrating neutrophils/monocyte-derived cells in controlling Legionella longbeachae infection via the IL-18R/IFN-γ/ROS pathway.

AdipoQ - a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro

AdipoQ quantifies adipocyte morphology and function in tissues and in vitro using an open-source ImageJ plugin for automated analysis.

Local synchronization of cilia and tissue-scale cilia alignment are sufficient for global metachronal waves

The paper shows that local cilia synchronization and tissue-scale alignment generate metachronal waves, enhancing fluid pumping in multiciliated epithelia.

Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization

This study shows that inhibiting soluble adenylyl cyclase (sAC) in human sperm prevents key functions needed for fertilization, suggesting sAC inhibitors as potential non-hormonal contraceptives.

CiliaQ - a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images

CiliaQ provides an open-source tool for automated ciliary morphology and fluorescence analysis in 2D, 3D, and 4D images, offering comprehensive and reproducible results.

Targeting Vitamin-D receptor (VDR) by a small molecule antagonist MeTC7 inhibits PD-L1 but controls THMYCN neuroblastoma growth PD-L1 independently

This study shows that MeTC7, a VDR antagonist, reduces PD-L1 expression in cancer cells and inhibits neuroblastoma growth independently of PD-L1.

Multifocal imaging for precise, label-free tracking of fast biological processes in 3D

This paper introduces a new open-source 3D reconstruction algorithm for multifocal imaging, enabling label-free, high-speed tracking of fast biological processes in 3D.

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

This study develops a nanobody-based method to target optogenetic tools to the primary cilium, enabling analysis of ciliary signaling and function in vitro and in vivo.

SpermQ - a simple analysis software to comprehensively study flagellar beating and sperm steering

SpermQ is a software tool that quantifies sperm flagellar beating and steering, enabling detailed analysis of motility patterns from time-lapse microscopy images.