DYNLL1 mis-splicing is associated with replicative genome instability in SF3B1 mutant cells
A. S. Tam, S. Tsai, E. Y.-C. Chang, V. Mathew, A. Shanks, T. R. Docking, A. Kumar, D. G. Bernard, A. Karsan, P. C. Stirling
This study shows SF3B1 mutations cause DYNLL1 mis-splicing, leading to genome instability through altered DNA repair and PARP inhibitor sensitivity.
bioRxiv · May 26, 2021 · PreprintCell Biology