Author

C. S. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

G. B. Morin· 5 shared A. Gagliardi· 1 shared A. J. Lazar· 1 shared A. K. Hofmann· 1 shared A. Moradian· 1 shared A. Pozner· 1 shared A. S. Tam· 1 shared B. Jensen· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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5 shared papersCancer Biology

G. B. Morin

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Author profile →

5 papers

Recent·Most cited

ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

A. Pozner, S. P. Verma, L. Li, S. Wang, J. J. Barrott, M. L. Nelson, J. S. E. Yu, G. L. Negri, S. Colborne, C. S. Hughes, J.-F. Zhu, S. L. Lambert, L. S. Carroll, K. Smith-Fry, M. G. Stewart, , K. B. Jones

This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.

bioRxiv · Sep 29, 2023Cancer Biology

Multi-omic analysis of CIC's functional networks reveals novel interaction partners and a potential role in mitotic fidelity

Y. Takemon, V. G. LeBlanc, J. Song, S. Y. Chan, S. D. Lee, D. L. Trinh, S. T. Ahmad, W. R. Brothers, R. D. Corbett, A. Gagliardi, A. Moradian, J. G. Cairncross, S. Yip, S. A. Aparicio, J. A. Chan, , M. A. Marra

This study uses multi-omic approaches to analyze CIC's functional networks, identifying novel interactions and revealing its role in mitotic fidelity and transcriptional splicing.

bioRxiv · Apr 6, 2023Cancer Biology

Recombinant T cell receptors specific for HLA-A*02:01-restricted neoepitopes containing KRAS codon 12 hotspot mutations

C. M. Rive, E. Yung, C. S. Hughes, S. D. Brown, G. Sharma, L. Dreolini, N. M. Mawji, C. Warren, J. Karasinska, J. M. Loree, D. T. Yapp, G. B. Morin, D. J. Renouf, D. F. Schaeffer, S. Turcotte, R. A. Holt

The paper identifies and characterizes T cell receptors specific for HLA-A*02:01-restricted KRAS codon 12 mutations in cancer, showing their reactivity and cytotoxic activity against tumor cells.

bioRxiv · Jun 15, 2020 · PreprintImmunology

High-flow Nano-chromatography Columns Facilitate Rapid and High-quality Proteome Analysis on Standard Nano-LC Hardware

C. S. Hughes, H. Adomat, S. LeBihan, C. Collins, P. Sorensen, G. B. Morin

This study demonstrates that high-flow nano-chromatography columns improve proteome analysis throughput without sacrificing data quality on standard nano-LC hardware.

bioRxiv · Dec 19, 2018 · PreprintBiochemistry

Genotoxin-induced transcriptional repression regulates selective protein aggregation

V. Mathew, A. S. Tam, K. L. Milbury, A. K. Hofmann, C. S. Hughes, G. B. Morin, C. J. Loewen, P. Stirling

The paper investigates how genotoxin-induced transcriptional repression affects protein aggregation by studying the splicing factor Hsh155 under alkylation stress.

bioRxiv · Mar 15, 2017Cell Biology