Author

E. Y.-C. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Assay:DNA methylation· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. P. Wells· 2 shared L.-A. Fournier· 2 shared P. C. Stirling· 2 shared P. Stirling· 2 shared S. Tsai· 2 shared Y. D. Zhu· 2 shared A. Karsan· 1 shared A. Kumar· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCell Biology

J. P. Wells

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4 papers

Recent·Most cited

RAD18 opposes transcription-associated genome instability through FANCD2 recruitment

J. Wells, E. Y.-C. Chang, L. Dinatto, J. White, P. Stirling

This study shows RAD18 recruits FANCD2 to suppress R-loops and transcription-replication conflicts, reducing genome instability during DNA replication stress.

bioRxiv · Jun 24, 2022Cell Biology

DYNLL1 mis-splicing is associated with replicative genome instability in SF3B1 mutant cells

A. S. Tam, S. Tsai, E. Y.-C. Chang, V. Mathew, A. Shanks, T. R. Docking, A. Kumar, D. G. Bernard, A. Karsan, P. C. Stirling

This study shows SF3B1 mutations cause DYNLL1 mis-splicing, leading to genome instability through altered DNA repair and PARP inhibitor sensitivity.

bioRxiv · May 26, 2021 · PreprintCell Biology

ARID1A regulates R-loop associated DNA replication stress

P. Stirling, S. Tsai, E. Y.-C. Chang, L.-A. Fournier, J. P. Wells, S. W. Minaker, Y. D. Zhu, A. Y.-H. Wang, Y. Wang, D. G. Huntsman

This study shows that ARID1A loss causes DNA replication stress linked to R-loops and transcription-replication conflicts in human cells.

bioRxiv · Nov 16, 2020Cell Biology

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts

E. Y.-C. Chang, J. P. Wells, S.-H. Tsai, Y. Coulombe, Y. A. Chan, Y. D. Zhu, L.-A. Fournier, P. Hieter, J.-Y. Masson, P. C. Stirling

The paper identifies MRE11-RAD50-NBS1's role in suppressing R-loops at transcription-replication conflicts through non-nucleolytic functions and Fanconi Anemia pathway interactions.

bioRxiv · Nov 17, 2018Cell Biology